Scholarly Output

Selected Publications & Presentations

491 citations · h-index 8 · i10-index 7 (Google Scholar, October 2026)

2026

CatRange enables robust prediction of enzyme variant kinetic regimes.

Sajeevan KA, Osinuga A, et al. PNAS Nexus, pgag309.

"Mutation-sensitive predictions of enzyme kinetic regimes built around protein sequence, substrate chemistry, and curated evidence."

Machine Learning Metabolic Engineering

2026

Machine Learning Reveals Proteome-Encoded Growth Predictors...

Osinuga A, Kathol M, Saha R. mSystems.

"Separating shared growth-associated proteins from environment-specific adaptation in R. palustris."

Machine Learning Systems Biology

2026

Multi-omics integration in genome-scale metabolic models...

Shahreen N, Osinuga A, et al. Molecular Omics 22(2).

"How molecular measurements become modeling constraints, rather than simply more input features."

Systems Biology Metabolic Engineering

2026

In-silico discovery of DPP-4 inhibitors from African medicinal plants.

Osinuga A, et al. The Nucleus 69(1):75-97.

"Molecular docking, ADMET, dynamics simulation for drug discovery from natural products."

Molecular Simulation Biomedical

2025

Robust prediction of enzyme variant kinetics with RealKcat.

bioRxiv.

"Precursor framework to CatRange using ESM/ChemBERTa embeddings for enzyme kinetics."

Machine Learning Metabolic Engineering

2025

Biochemical mechanisms and molecular interactions of vitamins in cancer therapy.

Cancer Pathogenesis and Therapy 3(01):3-15.

"Review connecting vitamin biochemistry to cancer therapeutic mechanisms."

Biomedical

2025

The role of machine learning in discovering biomarkers...neurodegenerative diseases.

NeuroMarkers 2(1):100034.

"Narrative review of ML applications in neurodegenerative disease biomarker discovery."

Machine Learning Biomedical

2024

Deciphering sphingolipid biosynthesis dynamics...

Osinuga A, et al. iScience 27(9):110675.

"Isotope-informed dynamic modeling of plant sphingolipid metabolism with explicit uncertainty treatment."

Systems Biology Metabolic Engineering

2024

Identification of novel phytotherapeutic agents for hypertrophic cardiomyopathy...

Genome Instability & Disease 5(6):262-286.

"Genetic mapping and computational analysis for cardiomyopathy drug discovery."

Biomedical Molecular Simulation

2024

Hyperparameter tuning in machine learning: A comprehensive review.

JERR 26(6):388-395.

"Comprehensive review of hyperparameter optimization strategies across ML architectures."

Machine Learning

2024

Transforming early microbial detection: biosensors for infectious diseases.

ABST 6:59-71.

"Innovative biosensors for early detection of emerging infectious diseases."

Biomedical

2024

Nanomedicine in cancer therapy: Advancing precision treatments.

ABST 6:105-119.

"Review of nanomedicine approaches advancing precision cancer therapy."

Biomedical

M.S. Thesis (2024)

Dynamic Metabolic Flux Analysis Amidst Data Variability...

UNL.

Systems Biology Metabolic Engineering

2023

Offset-Free Quasi-Infinite Horizon NMPC...

Bamimore AS, Rajhans C, Osinuga AB, et al. ASME JDSMC 145(10):101005.

"Parameter-adaptive nonlinear model predictive control ensuring offset-free tracking."

Process Control

2022

An online ML-based sensors clustering system...

Lee J, Osinuga AB, et al. Computers & Electronics in Agriculture 199:107139.

"Internet-of-Things (IoT) sensor placement optimization for controlled-environment agriculture."

Smart Agriculture Machine Learning

2021

Design, fabrication and interfacing of a cascaded three-tank system...

J Nigerian Academy of Engineering.

"Physical process platform design for research and education in process control."

Process Control

2021

A comparison of two ANNs for modelling and predictive control...

Bamimore AS, Rajhans C, Osinuga AB, Taiwo O. IFAC-PapersOnLine 54(21):145-150.

"Neural network architectures compared for multivariable predictive control."

Process Control Machine Learning

Selected Conference Presentations

  • "Catalytically Aware and Mutation-Resolved Kinetics Prediction..." AIChE Annual Meeting 2025, Boston (Oral)
  • "Predictive Modeling of Enzyme Kinetics Using Sequence-Based AI and Substrate Chemistry" AIChE 2025 (Poster)
  • "Multi-Omics Enabled Genome-Scale Model Reconstruction" AIChE 2025 (Oral, co-presenter)
  • "Addressing Temporal Variability in Metabolomics Through Dynamic Mechanistic Modeling" AIChE 2024, San Diego (Oral)
  • "Generalizable Dynamic Modeling Framework for Pathway-Level Metabolic Analysis" COBRA 2024 (Poster)
  • "Modeling Sphingolipid Metabolism and Prediction of ORM Proteins Using 13C MFA" AIChE 2023, Orlando (Oral)
  • "DMFA of Sphingolipid Metabolism in Arabidopsis" 26th International Symposium on Plant Lipids 2024, Minneapolis (Poster)
  • "Dynamic Metabolic Flux Analysis of Sphingolipid Biosynthesis" UNL Research Days 2024 (Poster, Honorable Mention)