Cancer Biology / Metabolic Modeling
How do cancer cells adapt when several resources become scarce?
Time-resolved analysis of pancreatic-cancer adaptation to hypoxia, acidity, and nutrient limitation.
In progress Question → model → evidence
Conceptual illustration of pancreatic-cancer adaptation under combined environmental stress, connecting time-resolved evidence to metabolic modeling.
View full figureThe Question
What metabolic pathways do pancreatic cancer cells activate when simultaneously stressed by low oxygen, acidic pH, and nutrient deprivation?
My Contribution
Building temporally resolved metabolic models, analyzing PDAC RNA-seq.
What the record shows
Reveals shifting dependencies across multiple simultaneous stress axes, informing context-specific vulnerabilities.
What this does—and does not—establish
Models suggest potential therapeutic targets based on transcriptomic shifts, which require subsequent empirical targeting to confirm essentiality.
Resources
Manuscript in preparation.