How does a system change its behavior?
My current research centers on biological systems: enzyme function, metabolism, and cellular adaptation. The methodological thread is the integration of learning, mechanistic constraints, and experimental evidence.
The Persistent Gap: Data-rich models can detect patterns, while mechanistic models can enforce feasibility. Yet neither alone reliably explains or redesigns complex biological behavior. My research portfolio addresses that gap across sectors and scales.
The Consistent Scientific Objective: Determine why a biological state is possible, which constraints sustain it, and how those constraints can be measured, challenged, or redesigned.
Explore the research
Choose an area, then explore each project's question, contribution, evidence, and resources.
Enzymes & Scientific AI
Protein sequence, substrate chemistry, and biochemical evidence for mutation-sensitive prediction and research workflows.
View projectsMetabolism & Adaptation
Proteome-informed growth prediction and isotope-informed dynamic modeling of changing metabolic systems.
View projectsDisease & Immune Response
Current investigations into pancreatic-cancer adaptation and multi-omics prediction of immune responses.
View projectsControl & Sensing
First-principles models, predictive control, and sensor placement for physical and agricultural systems.
View projectsEnzymes & Scientific AI
Enzyme Copilot
Metabolism & Adaptation
CorePredX: proteome & growth
Dynamic metabolic modeling
Disease & Immune Response
Pancreatic-cancer metabolism
DynPertBoost: immune response
Control & Sensing